Description

Depropylamino Chloro Propafenone-D5 is a deuterated analog of a key propafenone intermediate, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring accurate quantification and method validation in complex matrices, providing superior precision and reliability. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities specializing in pharmacokinetic studies, metabolism research, and quality control of active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of propafenone and its metabolites in biological samples (e.g., plasma, serum, urine) during bioanalytical method development and validation.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) profile of propafenone.
• Metabolite Identification: Aids in the structural elucidation and confirmation of propafenone metabolites using mass spectrometry.
• Quality Control & Assurance: Serves as a reference standard for the purity and stability testing of propafenone API and related pharmaceutical formulations.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and clinical trial sample analysis to ensure data accuracy and regulatory compliance.
• Forensic Toxicology: Employed in confirmatory testing for propafenone in forensic and clinical toxicology laboratories.

Basic Information

Product Name	Depropylamino Chloro Propafenone-D5
CAS No.	1346598-65-9
Molecular Formula	C15H16D5ClNO2
Molecular Weight	Contact for details
Synonyms	1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropan-2-one-d5; Propafenone-d5 Intermediate; 2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone-d5; 1-[2-Hydroxy-3-(propylamino-d5)propoxy]-3-phenylpropan-2-one; N-Propyl-3-phenyl-2-(2-hydroxy-3-propylamino-d5-propoxy)propiophenone; Deuterated Propafenone Impurity/Intermediate; Depropylamino Chloro Propafenone (D5)
EINECS	Contact for details

Quality Control

Our Depropylamino Chloro Propafenone-D5 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques such as NMR, HPLC, and Mass Spectrometry. We adhere to relevant industry standards for reference materials, and custom purity grades or specific isotopic enrichment levels are available upon request to meet your precise research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.