Description

Depropylamino Hydroxy Propafenone-D5 is a deuterium-labeled analog of a key propafenone metabolite, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity reference material is critical for ensuring the accuracy, precision, and regulatory compliance of pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and clinical research.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the precise quantification of propafenone and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track and quantify the metabolic pathways and clearance rates of propafenone in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing robust, reproducible, and GLP/GCP-compliant analytical assays.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports studies aimed at optimizing dosing regimens and understanding inter-patient variability in drug response.
• Pharmaceutical Impurity Profiling: Can be used in method development for assessing related substances and degradation products in drug substances and products.

Basic Information

Item	Detail
Product Name	Depropylamino Hydroxy Propafenone-D5
CAS No.	1346598-59-1
Molecular Formula	C14H16D5NO3
Molecular Weight	Contact for details
Synonyms	1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropan-2-one-d5; 2'-Hydroxypropafenone-d5; N-Despropyl-2'-hydroxypropafenone-d5; Propafenone Metabolite 5-D5; Depropyl 2-Hydroxypropafenone-D5; 5-Hydroxypropafenone-D5 (depropylamino analog); Deuterated Propafenone Metabolite Standard
EINECS	Contact for details

Quality Control

Every batch of Depropylamino Hydroxy Propafenone-D5 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with each shipment to support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.