Description

5-Fluoro Paliperidone is a key pharmaceutical intermediate and a fluorinated derivative of the antipsychotic agent paliperidone. This compound is of significant interest for its role in the research and development of novel active pharmaceutical ingredients (APIs) and for conducting advanced structure-activity relationship (SAR) studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on neuropharmacology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel paliperidone analogs and related antipsychotic compounds.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies to explore the impact of fluorination on drug potency, selectivity, and metabolic stability.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Process Chemistry: Employed in route scouting and process optimization for the scalable production of fluorinated active pharmaceutical ingredients (APIs).
• Metabolite Studies: Utilized as a standard in pharmacokinetic and metabolic profiling studies of fluorinated drug candidates.

Basic Information

Product Name	5-Fluoro Paliperidone
CAS No.	1346598-34-2
Molecular Formula	C23H27FN4O3
Molecular Weight	426.49 g/mol
Synonyms	9-Hydroxyrisperidone 5-Fluoro analog; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 5-Fluoropaliperidone; Paliperidone 5-Fluoro Derivative; 5-Fluoro-9-hydroxyrisperidone
EINECS	Contact for details

Quality Control

Our 5-Fluoro Paliperidone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.