Description

Colterol-D9 is a deuterium-labeled analog of colterol, a β-adrenergic receptor agonist, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise and stable isotopic labels for their research and quality control protocols.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of colterol and related compounds.
• Pharmacokinetic Studies: Enables accurate tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) in biological matrices.
• Metabolite Identification: Used in research to identify and quantify metabolites of colterol, aiding in understanding its metabolic pathways.
• Bioanalytical Method Development and Validation: Essential for developing, calibrating, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Doping Control Analysis: Potential application in sports anti-doping programs for the precise detection of β-2 agonist substances.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for drug substance and product testing.

Basic Information

Product Name	Colterol-D9
CAS No.	1346598-08-0
Molecular Formula	C12H10D9NO3 • (Salt form may vary)
Molecular Weight	~225.3 g/mol (base, D9)
Synonyms	(-)-α-[(tert-Butylamino)methyl]-3,4-dihydroxybenzyl alcohol-D9; 3,4-Dihydroxy-α-[(1,1-dimethylethyl)amino]methyl]benzenemethanol-D9; Colterol d9; Deuterated Colterol; [2H9]-Colterol; α-[(tert-Butylamino)methyl]protocatechuyl alcohol-D9; N-tert-Butylnoradrenaline-D9
EINECS	Contact for details

Quality Control

Our Colterol-D9 is manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (D-enrichment), chemical purity (by HPLC), and identification. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific pharmacopeial or internal specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR/HNMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.