Description

Rac Clopidogrel-D8 Hydrogen Sulfate (Major) is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in pharmaceutical research and development. This compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods, providing unmatched precision in pharmacokinetic and bioanalytical studies. It is an essential tool for analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in the development, quality control, and regulatory submission of clopidogrel-based therapies.

Application

• Primary Use as an Internal Standard: Essential for the precise quantification of clopidogrel and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS and GC-MS.
• Bioanalytical Method Development & Validation: A key component in establishing robust, sensitive, and selective analytical methods for clinical and preclinical studies.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in study subjects.
• Drug Metabolism Studies: Used to investigate metabolic pathways and identify metabolites of clopidogrel.
• Quality Control & Impurity Profiling: Supports the analysis of active pharmaceutical ingredients (APIs) and finished drug products for purity and stability.
• Forensic and Doping Control Analysis: Provides a reliable reference for the detection and confirmation of clopidogrel in specialized testing scenarios.

Basic Information

Product Name	Rac Clopidogrel-D8 Hydrogen Sulfate (Major)
CAS No.	1346598-07-9
Molecular Formula	C16H8D8ClNO2S • H2SO4
Molecular Weight	~ 541.99 g/mol (for free base C16H8D8ClNO2S)
Synonyms	Clopidogrel-d8 Hydrogen Sulfate; Methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dideutero-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5(4H)-acetate-d6 sulfate salt; Deuterated Clopidogrel Hydrogen Sulfate; Clopidogrel-d8 bisulfate; Rac Clopidogrel-d8 HSO4; Clopidogrel Internal Standard-d8; (rac)-Clopidogrel-d8 hydrogen sulfate
EINECS	Contact for details

Quality Control

Every batch of our Rac Clopidogrel-D8 Hydrogen Sulfate (Major) is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (1H, 13C), Mass Spectrometry, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and confirming the absence of interfering impurities. Our quality system is designed to meet the rigorous demands of GLP and GMP-compliant research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected m/z
Purity (HPLC)	≥ 98.0% (Area %)
Isotopic Purity (deuterium enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms to structure, no significant impurities
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.