Description

N,N'-Desethylene-N,N'-Diformyl Levofloxacin-D3 is a deuterated derivative and a key synthetic intermediate of the broad-spectrum fluoroquinolone antibiotic, Levofloxacin. This compound is of critical importance for pharmaceutical research and development, particularly in the synthesis of isotopically labeled drug substances for use as internal standards in bioanalytical methods. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in pharmacokinetic studies, drug metabolism research, and the development of high-precision mass spectrometry assays.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a stable, isotopically labeled internal standard for the accurate quantification of Levofloxacin and its metabolites in biological matrices (e.g., plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in the synthesis of labeled tracers to study the absorption, distribution, metabolism, and excretion (ADME) profile of Levofloxacin.
• Pharmaceutical Reference Standard: Acts as a certified reference material (CRM) for method development, validation, and quality control in analytical laboratories.
• Isotope Dilution Mass Spectrometry (IDMS): Essential for achieving high accuracy and precision in quantitative mass spectrometric analyses, minimizing matrix effects.
• Synthetic Intermediate: A crucial building block in the custom synthesis of other deuterated or structurally modified fluoroquinolone derivatives for research purposes.

Basic Information

Product Name	N,N'-Desethylene-N,N'-Diformyl Levofloxacin-D3
CAS No.	1346598-04-6
Molecular Formula	C19H17D3FNO4
Molecular Weight	354.37 g/mol (for monoisotopic mass)
Synonyms	Levofloxacin-D3 Desethylene Diformyl Derivative; (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Diformyl-D3 Derivative; Levofloxacin D3 Intermediate; Deuterated Levofloxacin Impurity/Intermediate; 1-Cyclopropyl-7-fluoro-8-methoxy-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4,3-ij]quinoline-2,9-dicarboxylic Acid D3 Derivative (related structural name).
EINECS	Contact for details

Quality Control

Our N,N'-Desethylene-N,N'-Diformyl Levofloxacin-D3 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (D-content), and identification data. We adhere to relevant industry standards for reference materials and can provide custom synthesis to meet specific purity or enrichment specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.