Description

Rac Dehydro-o-Desmethyl Venlafaxine-D6 CAS NO 1346598-00-2 is a deuterated isotopologue of a key metabolite of the antidepressant venlafaxine, serving as a critical internal standard for precise analytical quantification. This high-purity reference material is essential for ensuring accuracy and reliability in bioanalytical and pharmacokinetic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities involved in drug metabolism and pharmacokinetics (DMPK) research and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a stable isotope-labeled internal standard for the accurate quantification of O-desmethylvenlafaxine (ODV) and related metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioequivalence Studies: Enables precise measurement of drug and metabolite concentrations over time, critical for determining bioavailability, half-life, and bioequivalence of venlafaxine formulations.
• Forensic and Clinical Toxicology: Supports reliable testing for venlafaxine and its metabolites in forensic investigations and clinical settings to assess compliance, overdose, or intoxication.
• Drug Metabolism Research (DMPK): Facilitates detailed studies on the metabolic pathways, clearance, and disposition of venlafaxine in preclinical and clinical development.
• Method Development and Validation: Serves as a key component in developing, optimizing, and validating robust analytical methods according to FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Used in impurity profiling and stability testing of venlafaxine active pharmaceutical ingredient (API) and finished drug products.

Basic Information

Product Name	Rac Dehydro-o-Desmethyl Venlafaxine-D6
CAS No.	1346598-00-2
Molecular Formula	C16H19D6NO2
Molecular Weight	269.42 g/mol
Synonyms	O-Desmethylvenlafaxine-d6; Desvenlafaxine-d6; Didesmethylvenlafaxine-d6; [D6]-O-Desmethylvenlafaxine; 1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol-d6; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol-d6; (R/S)-O-Desmethylvenlafaxine-d6; ODV-d6
EINECS	Contact for details

Quality Control

Our Rac Dehydro-o-Desmethyl Venlafaxine-D6 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (HPLC), chemical purity, isotopic purity (D-enrichment), and residual solvents. We support compliance with relevant pharmacopeial and ICH guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chemical Purity	≥ 95.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.