Description

4-Chloro Maraviroc-D6 is a deuterated, chlorinated derivative of the HIV entry inhibitor Maraviroc, specifically designed for use as an internal standard in analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments requiring high-precision mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the precise quantification of Maraviroc and its metabolites in biological matrices.
• Pharmaceutical Research & Development: Used in method development and validation for bioanalytical assays during drug discovery and development phases.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration over time in plasma, serum, and tissue samples.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived components from endogenous compounds in complex samples.
• Quality Control & Assurance: Supports GLP/GMP-compliant analytical testing for batch release and stability testing of pharmaceutical products.
• Reference Material: Serves as a certified reference material for calibrating analytical instruments and ensuring regulatory compliance.

Basic Information

Product Name	4-Chloro Maraviroc-D6
CAS No.	1346597-32-7
Molecular Formula	C29H35D6ClF2N5O
Molecular Weight	523.13 g/mol (for D6 isotopologue)
Synonyms	4-Chloro Maraviroc-d6; 8-[4-Chlorophenyl]-N-[(4R)-4-[(3S)-1-[(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)amino]-2-methyl-3-oxobutyl]-2,2-dimethyl-1,3-thiazolidin-3-yl]-2-methyl-6,6,7,7,8,8-hexadeutero-5,6,7,8-tetrahydroquinoline-5-carboxamide; Deuterated 4-Chloro Maraviroc; Maraviroc Chloro Derivative-d6; Celsentri Derivative-d6; (4R,3S)-4-Chloro Maraviroc-d6
EINECS	Contact for details

Quality Control

Our 4-Chloro Maraviroc-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.