Description

Loracarbef-D5 is a deuterated analog of the second-generation cephalosporin antibiotic Loracarbef, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in bioanalytical and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development and validation for drug metabolism and residue analysis.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the accurate quantification of Loracarbef in biological matrices.
• Critical component in Pharmacokinetic and Bioequivalence Studies to determine drug concentration profiles in plasma, serum, and tissues.
• Reference material for Method Development and Validation in regulatory-compliant analytical laboratories (following FDA, EMA guidelines).
• Used in Drug Metabolism and Disposition (DMPK) research to track and elucidate metabolic pathways.
• Essential for conducting Residue Testing in food safety and environmental monitoring programs.
• High-purity chemical for use in Stable Isotope Labeling research and other advanced spectroscopic applications.

Basic Information

Product Name	Loracarbef-D5
CAS No.	1346597-29-2
Molecular Formula	C₁₆H₁₉D₅N₄O₅S
Molecular Weight	~ 410.47 g/mol
Synonyms	Loracarbef (phenyl-d5); Loracarbef-d5; (6R,7S)-7-[(R)-2-Amino-2-phenyl-d5-acetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; LY 163892-d5; KT-3777-d5; Lorabid-d5; Deuterated Loracarbef
EINECS	Contact for details

Quality Control

Every batch of Loracarbef-D5 is manufactured and tested under strict quality management systems to ensure the highest isotopic and chemical purity required for analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for identity, purity (HPLC), isotopic enrichment (NMR/MS), and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (¹H-NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.