Description

2,5-Dichloro-3-((trimethylsilyl)ethynyl)pyridine is a high-value, multi-functional organosilicon building block featuring a pyridine core with chlorine and ethynyl substituents. This compound is critical for advanced organic synthesis, particularly in the development of pharmaceuticals and functional materials, due to its unique reactivity profile. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, leveraging its halogenated heterocyclic structure.
• Material Science Building Block: Employed in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where the ethynyl group enables conjugation.
• Cross-Coupling Reactions: Acts as a versatile substrate in Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed cross-coupling reactions to form complex biaryl and acetylene-linked systems.
• Ligand and Catalyst Development: Utilized to synthesize novel nitrogen-containing ligands for metal catalysis and coordination chemistry.
• Chemical Biology Probes: Functions as a tagging or labeling reagent in the development of molecular probes for biochemical and diagnostic applications.

Basic Information

Product Name	2,5-Dichloro-3-((trimethylsilyl)ethynyl)pyridine
CAS No.	1346446-90-9
Molecular Formula	C10H11Cl2NSi
Molecular Weight	244.19 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]-2,5-dichloropyridine; 2,5-Dichloro-3-(2-trimethylsilylethynyl)pyridine; 2,5-Dichloro-3-(trimethylsilylethynyl)pyridine; 2,5-Dichloro-3-ethynylpyridine trimethylsilyl derivative; Pyridine, 2,5-dichloro-3-[(trimethylsilyl)ethynyl]-; TMS-Ethynyl-2,5-dichloropyridine
EINECS	Contact for details

Quality Control

Our 2,5-Dichloro-3-((trimethylsilyl)ethynyl)pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.