Description

L-Lysine, N2-[1-(4,4-Dimethyl-2,6-Dioxocyclohexylidene)Ethyl]- is a specialized, protected derivative of the essential amino acid L-Lysine, designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise, site-specific modifications in peptide synthesis and bioconjugation chemistry. It serves as a key building block for pharmaceutical R&D, particularly in the development of novel peptide-based therapeutics, prodrugs, and diagnostic agents where controlled reactivity and stability are paramount.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce protected lysine residues, enabling the construction of specific peptide sequences.
• Bioconjugation & Linker Chemistry: Serves as a functionalized handle for attaching payloads (e.g., drugs, dyes, polymers) to biomolecules like antibodies or proteins.
• Prodrug Development: Employed in designing prodrugs where the active moiety is linked via a cleavable bond to enhance bioavailability or targeting.
• Research & Development: Essential for academic and industrial research in medicinal chemistry, chemical biology, and proteomics.
• Biochemical Tool Development: Used to create affinity probes, enzyme inhibitors, and other biochemical tools for studying biological processes.

Basic Information

Product Name	L-Lysine, N2-[1-(4,4-Dimethyl-2,6-Dioxocyclohexylidene)Ethyl]-
CAS No.	1345510-53-3
Molecular Formula	C16H26N2O4
Molecular Weight	310.39 g/mol
Synonyms	Nε-(1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl)-L-lysine; Fmoc-Lys(Dde)-OH (common precursor form); Nα-Fmoc-Nε-Dde-L-lysine (related protected form); Dde-Lys; Lys(Dde); (2S)-6-{[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl]amino}-2-aminocaproic acid; 1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl-L-lysine derivative
EINECS	Contact for details

Quality Control

Our L-Lysine, N2-[1-(4,4-Dimethyl-2,6-Dioxocyclohexylidene)Ethyl]- is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and GMP-grade applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0% (Area %)
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.