Description

2-(2,6-Difluorophenyl)-2,2-Difluoroacetic Acid CAS NO 1344264-52-3 is a high-value, multi-fluorinated aromatic acetic acid derivative. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the synthesis of novel active ingredients. It is primarily required by R&D organizations and manufacturers in the agrochemical and pharmaceutical sectors developing next-generation products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the difluorophenyl and difluoroacetic acid moieties contribute to enhanced biological activity and metabolic stability.
• Material Science Research: Employed in the development of specialty polymers and advanced materials, where fluorine incorporation can alter surface properties and chemical resistance.
• Ligand and Catalyst Development: Acts as a precursor for creating novel fluorinated ligands used in catalytic processes, including cross-coupling reactions prevalent in fine chemical manufacturing.
• Fluorine Chemistry Studies: Serves as a valuable substrate for academic and industrial research exploring new fluorination methodologies and reaction mechanisms.

Basic Information

Product Name	2-(2,6-Difluorophenyl)-2,2-Difluoroacetic Acid
CAS No.	1344264-52-3
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	2,2-Difluoro-2-(2,6-difluorophenyl)acetic Acid; α,α-Difluoro-2,6-difluorophenylacetic Acid; 2-(2,6-Difluorophenyl)-2,2-difluoroethanoic Acid; DFDFPA; (2,6-Difluorophenyl)difluoroacetic Acid; Difluoro(2,6-difluorophenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our production of 2-(2,6-Difluorophenyl)-2,2-Difluoroacetic Acid adheres to stringent quality management protocols. Each batch is analyzed using advanced techniques like HPLC, GC, and NMR to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed specifications, and our quality systems support compliance with cGMP and ISO standards for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.