Description

2-[Ethyl({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl})Amino]-2-Methylpropanoic Acid is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). Its value lies in providing a sterically hindered, tertiary amino acid moiety, which is essential for introducing structural complexity and modifying the physicochemical properties of synthetic peptides. This high-purity intermediate is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides, enabling the incorporation of a sterically hindered 2-aminoisobutyric acid (Aib) analog.
• Pharmaceutical Research & Development: For constructing peptide-based drug candidates, including antimicrobial peptides, hormone analogs, and targeted therapeutics, where backbone modification is required for stability or activity.
• Bioconjugation and Probe Development: Serves as a versatile linker or spacer molecule in the creation of fluorescent probes, affinity tags, and peptide-biomolecule conjugates for diagnostic and research applications.
• Material Science and Specialty Polymers: Used in the synthesis of peptide-inspired polymers and biomaterials, where the unique structure imparts specific folding or self-assembly properties.
• Process Development and Scale-Up: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of peptide active pharmaceutical ingredients (APIs) at various scales.

Basic Information

Product Name	2-[Ethyl({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl})Amino]-2-Methylpropanoic Acid
CAS No.	1344079-11-3
Molecular Formula	C22H23NO5
Molecular Weight	381.42 g/mol
Synonyms	Fmoc-Aib(Et)-OH; Fmoc-N-ethyl-2-aminoisobutyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-ethyl-2-aminoisobutyric acid; 2-[(Ethyl-[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-methylpropanoic acid; Nα-Fmoc-N-ethyl-α-aminoisobutyric acid; Fmoc-N-ethyl-Aib-OH; (2-Methyl-2-{[(9H-fluoren-9-ylmethoxy)carbonyl](ethyl)amino}propanoic acid); Nα-(9-Fluorenylmethoxycarbonyl)-N-ethyl-2-aminoisobutyric acid
EINECS	Contact for details

Quality Control

Our 2-[Ethyl({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl})Amino]-2-Methylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity checks where applicable. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, ensuring compliance with the stringent requirements of pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.