Description

3-(2,4-Difluorophenyl)-1,1,1-Trifluoropropan-2-One is a high-value fluorinated aromatic ketone building block, prized for its unique structural motif that combines difluorophenyl and trifluoromethyl ketone functionalities. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its fluorine atoms are critical for modulating biological activity, metabolic stability, and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where fluorine substitution enhances efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Fluorinated Polymer Research: Employed as a monomer or modifier in the development of specialty polymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Chemical Biology & Proteomics: Utilized as a reactive handle or probe in activity-based protein profiling (ABPP) and the development of covalent inhibitors.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3-(2,4-Difluorophenyl)-1,1,1-Trifluoropropan-2-One
CAS No.	1343484-90-1
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	1,1,1-Trifluoro-3-(2,4-difluorophenyl)propan-2-one; 2,4-Difluoro-β,β,β-trifluoropropiophenone; 3-(2,4-Difluorophenyl)-1,1,1-trifluoroacetone; 2',4'-Difluoro-3,3,3-trifluoropropiophenone; 1-(2,4-Difluorophenyl)-3,3,3-trifluoropropan-2-one; DFTPO; 2,4-DFTPO
EINECS	Contact for details

Quality Control

Our production of 3-(2,4-Difluorophenyl)-1,1,1-Trifluoropropan-2-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.