Description

2,2-Difluoro-2-[2-(Trifluoromethyl)Phenyl]Acetic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and difluoroacetic acid moieties, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by material scientists exploring specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Active Ingredient Precursor: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a fluorinated core structure for developing advanced electronic display materials with improved performance characteristics.
• Specialty Polymer Modifier: Incorporated into polymer chains to impart unique chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and amide couplings to introduce a highly fluorinated phenylacetic acid group.
• Fluorine-19 NMR Spectroscopy: Can be used as a reference compound or a probe in magnetic resonance studies due to its distinct fluorine signature.

Basic Information

Product Name	2,2-Difluoro-2-[2-(Trifluoromethyl)Phenyl]Acetic Acid
CAS No.	1343107-31-2
Molecular Formula	C9H5F5O2
Molecular Weight	240.13 g/mol
Synonyms	2,2-Difluoro-2-(2-trifluoromethylphenyl)acetic Acid; α,α-Difluoro-2-(trifluoromethyl)phenylacetic Acid; 2-(Trifluoromethyl)benzoylfluoride, difluoroacetic acid derivative; [2-(Trifluoromethyl)phenyl](difluoro)acetic Acid; 2,2-Difluoro-2-(α,α,α-trifluoro-o-tolyl)acetic Acid; o-Trifluoromethylphenyl(difluoro)acetic Acid; DFTPAA; CAS 1343107-31-2
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-[2-(Trifluoromethyl)Phenyl]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is sensitive to strong bases and should be kept separate from alkaline compounds. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.