Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-Val-Osu CAS NO 1342820-49-8 is a specialized amino acid derivative, specifically a D-valine building block protected with the 9-fluorenylmethoxycarbonyl (Fmoc) group and activated as an N-hydroxysuccinimide (OSu) ester. This compound is a critical reagent in modern solid-phase peptide synthesis (SPPS), enabling the efficient and controlled incorporation of D-valine into peptide chains. It is primarily utilized by pharmaceutical R&D laboratories, biotech companies, and CROs engaged in the development of therapeutic peptides, peptidomimetics, and other bioactive molecules where precise stereochemistry is essential.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected, pre-activated amino acid derivative for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research: Key building block for the development of novel therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Design: Used to introduce the D-valine residue into non-natural peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Bioconjugation: The active ester (OSu) facilitates coupling reactions under mild conditions for labeling peptides or attaching them to other molecules or surfaces.
• Combinatorial Chemistry: Essential component in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: Used in biochemistry and molecular biology studies investigating protein-protein interactions, enzyme substrates, and receptor ligands.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl D-Val-Osu
CAS No.	1342820-49-8
Molecular Formula	C24H24N2O6
Molecular Weight	436.46 g/mol
Synonyms	Fmoc-D-Valine N-succinimidyl ester; Fmoc-D-Val-OSu; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-valine N-hydroxysuccinimide ester; N-α-Fmoc-D-valine succinimidyl ester; D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1,2,3,6-tetrahydro-2,5-dioxo-1H-pyrrol-1-yl ester; Fmoc-D-Val-ONSu; Fmoc-D-Valine OSu ester; N-Fmoc-D-valine N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for peptide synthesis. Every batch is characterized to confirm identity, purity, and suitability for SPPS applications. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay (HPLC), chiral purity, and moisture content to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.