Description

tert-Butyl 3-(cyclopropylamino)azetidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine scaffold. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of oncology, central nervous system (CNS) disorders, and anti-infectives.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug candidates, especially those targeting protein-protein interactions.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained azetidine ring.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker component connecting an E3 ligase ligand to a target protein ligand.
• Covalent Inhibitor Synthesis: The cyclopropylamino group can be utilized to introduce reactive warheads for the development of covalent drugs.
• Chemical Biology Probes: Employed in the creation of tool compounds for target identification and validation studies.
• Agrochemical Research: Potential intermediate in the discovery of new herbicides or fungicides with novel modes of action.

Basic Information

Product Name	tert-Butyl 3-(Cyclopropylamino)Azetidine-1-Carboxylate
CAS No.	1342433-96-8
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	1-Boc-3-(cyclopropylamino)azetidine; 3-(Cyclopropylamino)-1-azetidinecarboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 3-(cyclopropylamino)-1-azetidinecarboxylate; tert-Butyl 3-(cyclopropylamino)azetidine-1-carboxylate; 3-(Cyclopropylamino)azetidine-1-carboxylic acid tert-butyl ester; Azetidine-1-carboxylic acid, 3-(cyclopropylamino)-, 1,1-dimethylethyl ester; 1-N-Boc-3-(cyclopropylamino)azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(cyclopropylamino)azetidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.