Description

1-Difluoromethoxy-2-Ethynyl-Benzene is a high-purity, specialized aromatic compound featuring both difluoromethoxy and ethynyl functional groups. This unique structure makes it a valuable and versatile advanced pharmaceutical intermediate for modern drug discovery and development. It is primarily utilized by research institutions and fine chemical manufacturers engaged in synthesizing novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging the stability of the difluoromethoxy group.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: The ethynyl group provides a handle for creating novel ligands for catalysis and molecular recognition studies.
• Fluorine Chemistry: An important reagent for introducing difluoromethoxy motifs into target molecules, a common strategy in bioisosteric replacement.
• Academic & Industrial R&D: Employed in exploratory chemistry for developing new synthetic methodologies and discovering novel compounds.

Basic Information

Item	Details
Product Name	1-Difluoromethoxy-2-Ethynyl-Benzene
CAS No.	1342158-87-5
Molecular Formula	C9H6F2O
Molecular Weight	168.14 g/mol
Synonyms	2-Ethynyl-1-(difluoromethoxy)benzene; o-(Difluoromethoxy)phenylacetylene; 1-(Difluoromethoxy)-2-ethynylbenzene; 2-Ethynylphenyl difluoromethyl ether; Benzene, 1-(difluoromethoxy)-2-ethynyl-; (2-Ethynylphenyl)difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-Difluoromethoxy-2-Ethynyl-Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and IR spectroscopy to confirm identity and purity. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.