Description

1-Bromo-4-(Chloromethyl)-2,5-Difluorobenzene is a high-purity, multi-functional halogenated benzene derivative of significant importance in advanced organic synthesis. This compound serves as a versatile and critical building block for the construction of complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for creating active pharmaceutical ingredients (APIs), liquid crystal materials, and functionalized ligands.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing difluorobenzene and halogenated aryl motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging its reactive bromo and chloromethyl groups for further functionalization.
• Liquid Crystal Materials: Serves as a core building block for the production of fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl systems.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and constructing functionalized aromatic scaffolds in academic and industrial labs.

Basic Information

Product Name	1-Bromo-4-(Chloromethyl)-2,5-Difluorobenzene
CAS No.	1341660-62-5
Molecular Formula	C7H4BrClF2
Molecular Weight	241.46 g/mol
Synonyms	2,5-Difluoro-4-bromobenzyl chloride; 4-Bromo-2,5-difluorobenzyl chloride; 1-Bromo-4-(chloromethyl)-2,5-difluorobenzene; (4-Bromo-2,5-difluorophenyl)methyl chloride; Benzene, 1-bromo-4-(chloromethyl)-2,5-difluoro-; 4-Bromo-α,2,5-trifluorotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Chloromethyl)-2,5-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.