Description

1-Fmoc-3-(Hydroxymethyl)Piperidine is a high-purity, protected piperidine derivative used as a critical building block in advanced organic synthesis. This compound is essential for the controlled introduction of the 3-(hydroxymethyl)piperidine moiety into complex molecular architectures, particularly in peptide and peptidomimetic chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the solid-phase and solution-phase synthesis of complex drug candidates and bioactive molecules.
• Peptide Chemistry: Used for the incorporation of the piperidine scaffold into peptide backbones to modify conformation, stability, and biological activity.
• Combinatorial Library Synthesis: Serves as a versatile building block for creating diverse compound libraries for high-throughput screening in drug discovery.
• Protecting Group Strategy: The Fmoc (9-fluorenylmethoxycarbonyl) group provides orthogonal protection for amine functionalities, enabling sequential synthesis.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	1-Fmoc-3-(Hydroxymethyl)Piperidine
CAS No.	1341328-61-7
Molecular Formula	C22H25NO3
Molecular Weight	351.44 g/mol
Synonyms	1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(hydroxymethyl)piperidine; 3-(Hydroxymethyl)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperidine; 1-Fmoc-3-piperidinemethanol; 3-(Hydroxymethyl)piperidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester; Fmoc-3-(hydroxymethyl)piperidine; 1-N-Fmoc-3-(hydroxymethyl)piperidine; 1-[(9-Fluorenylmethyloxycarbonyl)]-3-(hydroxymethyl)piperidine
EINECS	Contact for details

Quality Control

Our 1-Fmoc-3-(Hydroxymethyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.