Description

2-[(Cyclopropylmethyl)[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Acetic Acid is a specialized Fmoc-protected amino acid derivative designed for advanced peptide synthesis. This compound matters as a critical building block for the controlled introduction of the cyclopropylmethyl-modified amino acid moiety into complex peptide chains, enabling the development of novel therapeutic candidates. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and CROs (Contract Research Organizations) engaged in the discovery and synthesis of peptide-based drugs, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of peptides on resin.
• Peptide Drug Discovery: Used to incorporate the unique cyclopropylmethyl side chain into peptide sequences to modulate biological activity, stability, and receptor binding affinity.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-conjugates for imaging, targeting, and diagnostic applications.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions and enzyme mechanisms by introducing specific structural modifications.
• Process Development & Scale-Up: Supports the transition from milligram-scale research to gram/kilogram-scale production for preclinical and clinical trial material.

Basic Information

Product Name	2-[(Cyclopropylmethyl)[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Acetic Acid
CAS No.	1341306-32-8
Molecular Formula	C21H21NO4
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-Cpr-OH; Fmoc-Cyp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(cyclopropylmethyl)glycine; N-Fmoc-N-(cyclopropylmethyl)glycine; (Fmoc-Cpr)OH; 2-[(Cyclopropylmethyl)(Fmoc)amino]acetic acid; Nα-Fmoc-Nα-(cyclopropylmethyl)glycine; Fmoc-N-(cyclopropylmethyl)glycine
EINECS	Contact for details

Quality Control

Our 2-[(Cyclopropylmethyl)[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis where applicable, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, consistency, and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.