Description

Pentixafor is a potent and selective antagonist of the C-X-C chemokine receptor type 4 (CXCR4), a key target in oncology and immunology research. Its high specificity makes it a critical tool for studying tumor metastasis, stem cell mobilization, and inflammatory processes. This compound is essential for pharmaceutical R&D, diagnostic development, and advanced academic research in cancer biology and immunotherapies. Pentixafor CAS NO 1341207-62-2 represents a high-purity standard for investigative and potential clinical applications.

Application

• CXCR4 Receptor Research: Fundamental tool for in vitro and in vivo studies targeting the CXCR4/CXCL12 axis.
• Oncology & Metastasis Studies: Used to investigate the role of CXCR4 in cancer cell migration, invasion, and organ-specific metastasis.
• Diagnostic Imaging Agent Precursor: Serves as a precursor for radiolabeled analogs (e.g., [68Ga]Pentixafor) used in Positron Emission Tomography (PET) imaging of CXCR4 expression in tumors.
• Stem Cell Mobilization Research: Applied in studies to understand and manipulate hematopoietic stem cell release from bone marrow.
• Immunology & Inflammation Models: Utilized to probe CXCR4 function in autoimmune diseases, HIV infection, and wound healing.
• Therapeutic Development: Acts as a reference compound for screening and developing novel CXCR4-targeted therapeutics.
• Academic & Pharmaceutical R&D: Critical for basic research and drug discovery programs in major biotech and pharmaceutical companies.

Basic Information

Product Name	Pentixafor
CAS No.	1341207-62-2
Molecular Formula	C31H50N8O7S
Molecular Weight	678.85 g/mol
Synonyms	Cyclopentyl-[2-[[2-[[2-[[2-[[(4-ethoxyphenyl)-methylamino]methyl]-1H-imidazol-4-yl]methylamino]acetyl]amino]acetyl]amino]acetyl]amino]acetic acid; Pentixafor (USAN); UNII-0F65R2W89H; CXCR4 Antagonist; AMD 3465 Hexahydrobromide (related salt form); 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] (core structure reference); CPCR4 Antagonist
EINECS	Contact for details

Quality Control

Our Pentixafor is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Quality is verified through comprehensive analytical testing including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.