Description

(9H-Fluoren-9-Yl)Methyl 2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate is a specialized, high-purity chemical building block primarily used in advanced organic synthesis. This compound is valued for its role as a protected intermediate, enabling the controlled construction of complex molecular architectures. It is essential for research and development in the pharmaceutical and biotechnology sectors, particularly in peptide synthesis and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis as a building block for introducing specific functional groups.
• Protecting Group Chemistry: Serves as a reagent for the introduction of the Fmoc (9-fluorenylmethoxycarbonyl) protecting group on amines or alcohols in sensitive synthetic pathways.
• Bioconjugation: Employed in the development of linker molecules for antibody-drug conjugates (ADCs) and other targeted therapeutic modalities.
• Academic & Industrial R&D: A critical material for medicinal chemistry research, process development, and scaling up novel synthetic routes.
• Custom Synthesis: Serves as a starting point for contract research organizations (CROs) and CDMOs producing bespoke fine chemicals for clients.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methyl 2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate
CAS No.	1339668-62-0
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-2-(hydroxymethyl)pyrrolidine-1-carboxylate; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(hydroxymethyl)pyrrolidine; 2-(Hydroxymethyl)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine; N-Fmoc-2-(hydroxymethyl)pyrrolidine; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(hydroxymethyl)azolidine; Fmoc-Hmp-OH (common abbreviation); (9-Fluorenylmethyl) 2-(hydroxymethyl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methyl 2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.