Description

2-(2,4-Difluorophenyl)-2,2-Difluoroacetic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters as a key intermediate for introducing the difluoroacetic acid moiety into complex molecular architectures, enabling precise modulation of physicochemical properties. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in the creation of protease inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for antiviral and anticancer drug candidates.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the fluorine atoms enhance bioavailability and environmental stability.
• Material Science: Serves as a monomer or modifier in the production of specialty polymers and advanced materials with tailored surface properties.
• Chemical Research: Employed as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Ligand & Catalyst Development: Useful for synthesizing novel fluorinated ligands for metal-catalyzed cross-coupling reactions.

Basic Information

Product Name	2-(2,4-Difluorophenyl)-2,2-Difluoroacetic Acid
CAS No.	1339147-37-3
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	2,2-Difluoro-2-(2,4-difluorophenyl)acetic Acid; α,α-Difluoro-2,4-difluorophenylacetic Acid; 2-(2,4-Difluorophenyl)-2,2-difluoroethanoic Acid; DFDFPA; (2,4-Difluorophenyl)difluoroacetic Acid; Difluoro(2,4-difluorophenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our 2-(2,4-Difluorophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.