Description

2-(4-Cyclopropyl-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery, catalyst development, and material science applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated and cyclopropyl-substituted aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the specific phenyl-boronate moiety is required for structure-activity optimization.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as polymers for OLEDs and OFETs.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for imaging and diagnostic applications due to its biocompatible coupling chemistry.
• Custom Synthesis and R&D: A versatile starting material for contract research organizations (CROs) and academic laboratories engaged in novel organic molecule construction.

Basic Information

Product Name	2-(4-Cyclopropyl-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1338718-13-0
Molecular Formula	C15H20BFO2
Molecular Weight	262.13 g/mol
Synonyms	4-Cyclopropyl-2-fluorophenylboronic acid pinacol ester; (4-Cyclopropyl-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-4-cyclopropylbenzeneboronic acid pinacol ester; 4-Cyclopropyl-2-fluorobenzeneboronic acid pinacol ester; 2-(4-Cyclopropyl-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Cyclopropyl-2-fluoro-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene
EINECS	Contact for details

Quality Control

Our 2-(4-Cyclopropyl-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP development and commercial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.