Description

Propargyl-Peg2-Ch2Cootbu is a specialized bifunctional PEG linker featuring a propargyl group and a tert-butyl ester-protected carboxylic acid, widely used in bioconjugation and materials science. Its core value lies in enabling precise, copper-catalyzed click chemistry reactions for the stable attachment of molecules, peptides, or probes to various substrates. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced polymer synthesis who require reliable and efficient crosslinking agents.

Application

• Bioconjugation and ADC Development: Serves as a key linker for attaching cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) research and production.
• Proteomics and Biomarker Labeling: Used for site-specific labeling of proteins and peptides via click chemistry for imaging, tracking, and interaction studies.
• Polymer and Materials Functionalization: Enables the introduction of alkyne handles onto polymer backbones or nanoparticle surfaces for further modular assembly.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a versatile building block for incorporating PEG spacers and clickable functionalities into synthetic peptides.
• Diagnostic Reagent Preparation: Utilized in the synthesis of fluorescent probes, biosensors, and other diagnostic tools requiring stable covalent linkages.
• Surface Modification and Immobilization: Facilitates the covalent attachment of biomolecules to chips, beads, or other solid supports for assay development.

Basic Information

Product Name	Propargyl-Peg2-Ch2Cootbu
CAS No.	1338564-53-6
Molecular Formula	C16H28O6
Molecular Weight	316.39 g/mol
Synonyms	2,5,8,11-Tetraoxatetradec-13-ynoic acid, 14-tert-butyl ester; Propargyl-PEG2-CH2COOH-tBu; 3,6,9-Trioxa-12-dodecynoic acid, 13-tert-butyl ester; tert-Butyl 3,6,9-trioxa-12-dodecynoate; Propargyl-PEG2-acid t-butyl ester; Alkyne-PEG2-t-butyl ester; 1-tert-Butyl 14-(2-propyn-1-yl) 2,5,8,11-tetraoxatetradecanedioate
EINECS	Contact for details

Quality Control

Our Propargyl-Peg2-Ch2Cootbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research and cGMP-compliant manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Keep away from strong acids and organic solvents. Under these conditions, the product is stable for extended periods.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.