Description

3-(Trifluoromethyl)-1,2,4-Oxadiazol-5-Ol is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl-substituted oxadiazole scaffold, which is crucial for developing novel compounds with enhanced metabolic stability and bioavailability. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of new active ingredients, as well as by specialty chemical manufacturers exploring advanced material science applications.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibitors or receptor modulators.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, or insecticides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or electronic materials that require fluorinated heterocyclic components.
• Chemical Biology Probes: Employed in the construction of molecular probes and tags for studying biological processes due to its distinct structural and potential spectroscopic properties.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(Trifluoromethyl)-1,2,4-Oxadiazol-5-Ol
CAS No.	1338494-62-4
Molecular Formula	C3HF3N2O2
Molecular Weight	154.05 g/mol
Synonyms	5-Hydroxy-3-(trifluoromethyl)-1,2,4-oxadiazole; 3-(Trifluoromethyl)-1,2,4-oxadiazol-5-ol; 5-Hydroxy-3-(trifluoromethyl)-1,2,4-oxadiazole; 1,2,4-Oxadiazol-5-ol, 3-(trifluoromethyl)-; 3-Trifluoromethyl-1,2,4-oxadiazol-5-ol; 5-Hydroxy-3-trifluoromethyl-1,2,4-oxadiazole
EINECS	Contact for details

Quality Control

Our production of 3-(Trifluoromethyl)-1,2,4-Oxadiazol-5-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assay and NMR for structural confirmation. Certificates of Analysis (COA) detailing all test results are provided and available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.