Description

(R)-3-(tert-Butyl)-4-(2,6-Diisopropoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is a high-value, chiral organophosphorus compound featuring a unique oxaphosphole heterocycle. This compound matters as a sophisticated ligand precursor or chiral auxiliary in asymmetric catalysis, enabling the synthesis of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by pharmaceutical R&D laboratories and specialty chemical manufacturers developing novel catalytic processes and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Catalysis: Serves as a precursor for chiral phosphine or phosphite ligands in transition metal-catalyzed reactions such as hydrogenation, hydroformylation, and cross-coupling.
• Pharmaceutical Intermediate: Used in the research and development of enantiomerically pure drug candidates, particularly in constructing complex molecular architectures.
• Chiral Auxiliary: Can be employed to induce stereoselectivity in organic synthesis, controlling the formation of specific stereocenters.
• Material Science Research: Investigated for the development of novel chiral materials or polymers with specific optical properties.
• Agrochemical Synthesis: Potential application in the asymmetric synthesis of advanced, biologically active crop protection agents.
• Academic & Industrial R&D: A valuable tool for chemists in universities and corporate labs exploring new methodologies in organometallic and synthetic chemistry.

Basic Information

Product Name	(R)-3-(tert-Butyl)-4-(2,6-Diisopropoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole
CAS No.	1338454-38-8
Molecular Formula	C24H33O3P
Molecular Weight	400.49 g/mol
Synonyms	(R)-3-tert-Butyl-4-(2,6-diisopropoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; (R)-3-(tert-Butyl)-4-(2,6-diisopropoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole; (R)-3-tert-Butyl-4-(2,6-diisopropoxyphenyl)-2,3-dihydro-1,3-benzoxaphosphole; (R)-H8-BINOL-Di-iPr-Phosphole Derivative; Chiral Oxaphosphole Derivative; (R)-DTB-DiPPO (common abbreviation)
EINECS	Contact for details

Quality Control

Our (R)-3-(tert-Butyl)-4-(2,6-Diisopropoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphole is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification and NMR for structural confirmation, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to moisture and oxygen; for long-term storage, consider under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.