Description

Ethyl 3-(4,4-Difluoro-Cyclohexyl)-3-Oxo-Propanoate is a high-value fluorinated ketoester building block, essential for advanced organic synthesis. Its unique structure, featuring a difluorocyclohexyl moiety, provides critical properties for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the metabolically stable difluorocyclohexyl group.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where fluorine substitution enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty monomers or additives aimed at developing polymers with specific optical or surface properties.
• Chemical Biology Probes: Employed in the synthesis of fluorinated probes and tags for studying biological processes and protein interactions.
• Liquid Crystal & OLED Materials: Acts as an intermediate for fluorinated components used in electronic display technologies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise fluorination patterns.

Basic Information

Product Name	Ethyl 3-(4,4-Difluoro-Cyclohexyl)-3-Oxo-Propanoate
CAS No.	1338247-37-2
Molecular Formula	C11H16F2O3
Molecular Weight	234.24 g/mol
Synonyms	Ethyl 4,4-Difluorocyclohexanecarbonylacetate; 3-Oxo-3-(4,4-difluorocyclohexyl)propanoic Acid Ethyl Ester; Ethyl (4,4-Difluorocyclohexanoyl)acetate; 4,4-Difluorocyclohexanecarboxylic Acid Ethyl Ester (Keto Form); Acetic Acid, 2-(4,4-Difluorocyclohexyl)-2-oxo-, Ethyl Ester; Ethyl 3-(4,4-Difluorocyclohexyl)-3-oxopropionate
EINECS	Contact for details

Quality Control

Our production of Ethyl 3-(4,4-Difluoro-Cyclohexyl)-3-Oxo-Propanoate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.