Description

4-((tert-Butyldimethylsilyl)Oxy)-n-Methylbenzamide is a high-purity, protected intermediate of significant value in advanced organic synthesis. This compound matters because it provides a versatile and stable building block for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and other specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those requiring protected phenolic or benzamide functionalities.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Peptide Mimetics & PROTACs: Serves as a crucial component in the design and synthesis of peptide analogs and Proteolysis Targeting Chimeras (PROTACs).
• Material Science Precursor: Acts as a monomer or functionalizing agent in the development of advanced polymers and specialty materials.
• Academic & Contract Research: Essential reagent for methodology development and complex molecule synthesis in academic and CRO (Contract Research Organization) laboratories.
• Custom Synthesis: Employed by fine chemical manufacturers for the bespoke production of client-specified target molecules.

Basic Information

Product Name	4-((tert-Butyldimethylsilyl)Oxy)-n-Methylbenzamide
CAS No.	1337980-46-7
Molecular Formula	C14H23NO2Si
Molecular Weight	265.43 g/mol
Synonyms	N-Methyl-4-[(tert-butyldimethylsilyl)oxy]benzamide; 4-(tert-Butyldimethylsiloxy)-N-methylbenzamide; 4-(TBDMSO)-N-methylbenzamide; 4-Hydroxy-N-methylbenzamide TBDMS ether; p-[(tert-Butyldimethylsilyl)oxy]-N-methylbenzamide; Benzamide, N-methyl-4-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; TBDMS-protected N-methyl-4-hydroxybenzamide
EINECS	Contact for details

Quality Control

Our 4-((tert-Butyldimethylsilyl)Oxy)-n-Methylbenzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment to guarantee batch-to-batch consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.