Description

Benzonitrile, 3-[(1R)-1-Aminoethyl]-2-Methyl- CAS NO 1336454-90-0 is a chiral benzonitrile derivative featuring an aminoethyl side chain, serving as a high-value pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), where its specific stereochemistry is essential for biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries developing novel therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced, stereospecific pesticides and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Chemical Research: Valuable reference standard and starting material in medicinal chemistry and process development.
• Fine Chemical Production: Employed in the manufacture of other specialty chemicals requiring its unique benzonitrile core structure.

Basic Information

Product Name	Benzonitrile, 3-[(1R)-1-Aminoethyl]-2-Methyl-
CAS No.	1336454-90-0
Molecular Formula	C10H12N2
Molecular Weight	160.22 g/mol
Synonyms	(R)-3-(1-Aminoethyl)-2-methylbenzonitrile; 2-Methyl-3-[(1R)-1-aminoethyl]benzonitrile; 3-[(1R)-1-Aminoethyl]-2-methylbenzonitrile; Benzonitrile, 3-[(1R)-1-aminoethyl]-2-methyl-; (1R)-1-(3-Cyano-2-methylphenyl)ethanamine; (R)-1-(3-Cyano-2-methylphenyl)ethanamine; (R)-α-Methyl-3-cyano-2-methylbenzeneethanamine
EINECS	Contact for details

Quality Control

Our Benzonitrile, 3-[(1R)-1-Aminoethyl]-2-Methyl- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by IR and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.