Description

α-[[(Z)-2-(2-Amino-4-Thiazolyl)-2-[(Carboxymethoxy)Imino]Acetyl]Amino]-2-[(2R)-5-Methyl-7-Oxo-1,2,5,7-Tetrahydro-4H-Furo[3,4-D][1,3]Thiazin-2-Yl]Acetic Acid is a high-purity, advanced pharmaceutical intermediate critical for the synthesis of next-generation cephalosporin antibiotics. This compound is engineered to serve as a key building block, enabling the development of broad-spectrum antibacterial agents with enhanced stability and efficacy. It is essential for research institutions and pharmaceutical manufacturers focused on innovating within the anti-infective and antimicrobial therapeutic segments.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Primary use as a sophisticated synthon in the multi-step synthesis of novel cephalosporin-class antibiotics.
• Antibacterial Drug Research & Development: A crucial starting material for medicinal chemists developing new compounds to combat drug-resistant bacterial infections.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for process optimization and commercial-scale GMP manufacturing of final drug substances.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory filing (e.g., FDA, EMA dossiers) of related antibiotic products.
• Bioconjugation & Prodrug Development: Potential utility in creating targeted antibiotic therapies or prodrugs due to its reactive functional groups.

Basic Information

Product Name	α-[[(Z)-2-(2-Amino-4-Thiazolyl)-2-[(Carboxymethoxy)Imino]Acetyl]Amino]-2-[(2R)-5-Methyl-7-Oxo-1,2,5,7-Tetrahydro-4H-Furo[3,4-D][1,3]Thiazin-2-Yl]Acetic Acid
CAS No.	1335475-08-5
Molecular Formula	C18H19N5O8S2
Molecular Weight	505.50 g/mol
Synonyms	(2R)-2-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl]amino]-2-(5-methyl-7-oxo-1,2,5,7-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)acetic acid; Cephalosporin intermediate 1335475-08-5; 7β-[2-(2-Aminothiazol-4-yl)-(Z)-2-(carboxymethoxyimino)acetamido]-3-[(5-methyl-7-oxo-1,2,5,7-tetrahydro-4H-furo[3,4-d]thiazin-2-yl)methyl]-3-cephem-4-carboxylic acid derivative; Furo[3,4-d]thiazine acetic acid intermediate; Advanced cephalosporin side chain
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems. Every batch is subjected to rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets exacting standards for pharmaceutical R&D and GMP production. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. Our quality systems support compliance with ICH Q7 guidelines and relevant pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can impact stability and purity. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2R isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.