Description

{2-[(2,4-Difluorophenyl)Methoxy]Phenyl}Boronic Acid CAS NO 1335234-26-8 is a specialized organoboron compound featuring a difluorinated aromatic ether linker, making it a valuable building block in modern synthetic chemistry. Its primary value lies in its role as a key intermediate in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for forming carbon-carbon bonds. This high-purity boronic acid is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients. It enables the precise construction of complex molecular architectures required for advanced drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used to construct novel herbicide and fungicide molecules, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced organic electronic materials, such as polymers for OLEDs or sensors.
• Ligand and Catalyst Development: Employed in the creation of novel bidentate ligands for transition metal catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	{2-[(2,4-Difluorophenyl)Methoxy]Phenyl}Boronic Acid
CAS No.	1335234-26-8
Molecular Formula	C13H11BF2O3
Molecular Weight	264.04 g/mol
Synonyms	[2-(2,4-Difluorophenoxy)phenyl]boronic acid; 2-(2,4-Difluorophenoxy)benzeneboronic acid; (2-((2,4-Difluorophenyl)oxy)phenyl)boronic acid; B-[2-[(2,4-Difluorophenyl)oxy]phenyl]-Boronic acid; 2-[(2,4-Difluorophenoxy)]phenylboronic acid; (2-(2,4-Difluorophenoxy)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Our {2-[(2,4-Difluorophenyl)Methoxy]Phenyl}Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We can support development projects with custom specifications aligned with ICH Q3 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.