Description

Zoledronic Acid CAS NO 1334703-07-9 is a high-potency bisphosphonate compound, serving as the active pharmaceutical ingredient (API) for the treatment of bone-related disorders. Its primary value lies in its superior efficacy in inhibiting osteoclast-mediated bone resorption, making it a critical component in advanced pharmaceutical formulations. This product is essential for manufacturers in the global pharmaceutical industry developing treatments for osteoporosis, hypercalcemia of malignancy, and Paget's disease of bone.

Application

• Primary Active Pharmaceutical Ingredient (API) in injectable formulations for osteoporosis treatment.
• Key component in oncology-supportive care drugs for managing skeletal-related events and hypercalcemia of malignancy.
• Used in the research and development of novel bone-targeting therapeutic agents and drug delivery systems.
• Essential raw material for compounding pharmacies and specialty pharmaceutical manufacturers.
• Reference standard in analytical laboratories for quality control and method validation of bisphosphonate drugs.
• Intermediate in the synthesis of more complex, bone-specific radiopharmaceuticals and diagnostic agents.

Basic Information

Item	Details
Product Name	Zoledronic Acid
CAS No.	1334703-07-9
Molecular Formula	C5H10N2O7P2
Molecular Weight	272.09 g/mol
Synonyms	Zoledronate; Zoledronic Acid Monohydrate; CGP 42446; (1-Hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid; Zometa (trade name); Reclast (trade name); Aclasta (trade name); IUPAC: (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(phosphonic acid)
EINECS	Contact for details

Quality Control

Our Zoledronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmaceutical standards, with specifications aligned with major pharmacopoeial requirements. A detailed Certificate of Analysis (COA), documenting identity, purity, and impurity profiles, is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
pH (1% Solution)	2.0 - 3.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.