Description

1-Boc-3-Cyano-3-Fluoropyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a unique fluorinated pyrrolidine scaffold. This compound is critical for medicinal chemists seeking to modulate the pharmacokinetic and metabolic properties of drug candidates through strategic fluorine incorporation. It is primarily utilized in the research and development of novel therapeutics, including protease inhibitors and other small-molecule drugs targeting the central nervous system and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Protease Inhibitor Development: Used in the research of inhibitors for various proteases, where the fluoropyrrolidine moiety can enhance binding affinity and selectivity.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) exploration by introducing fluorine and cyano groups to optimize potency, metabolic stability, and lipophilicity.
• Synthesis of Fluorinated Bioisosteres: Serves as a precursor for creating fluorinated analogs of natural amino acids or other bioactive molecules.
• Agrochemical Research: Potential use in developing novel fluorinated compounds for crop protection agents.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the life sciences industry.

Basic Information

Product Name	1-Boc-3-Cyano-3-Fluoropyrrolidine
CAS No.	1334675-01-2
Molecular Formula	C10H15FN2O2
Molecular Weight	214.24 g/mol
Synonyms	tert-Butyl 3-cyano-3-fluoropyrrolidine-1-carboxylate; 3-Fluoro-3-cyanopyrrolidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-cyano-3-fluoropyrrolidine; 3-Cyano-3-fluoro-1-Boc-pyrrolidine; 3-Fluoro-1-Boc-3-cyanopyrrolidine; N-Boc-3-cyano-3-fluoropyrrolidine; 1-Boc-3-fluoro-3-cyanopyrrolidine
EINECS	Contact for details

Quality Control

Every batch of 1-Boc-3-Cyano-3-Fluoropyrrolidine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications suitable for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.