Description

tert-Butyl ((3-Aminocyclobutyl)Methyl)Carbamate is a high-purity, protected amine building block of significant importance in modern organic synthesis. This compound is specifically engineered to serve as a critical intermediate in the development of novel pharmaceutical agents and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of complex small-molecule drug candidates and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Peptidomimetic Synthesis: Used to introduce the constrained 3-aminocyclobutyl moiety into peptide backbones, enhancing metabolic stability and bioavailability.
• Ligand and Probe Development: Serves as a versatile scaffold for creating chemical probes and high-affinity ligands in drug discovery programs.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides orthogonal protection for the primary amine, enabling complex multi-step synthetic sequences.
• Chemical Library Synthesis: Employed in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl ((3-Aminocyclobutyl)Methyl)Carbamate
CAS No.	1334499-53-4
Molecular Formula	C10H20N2O2
Molecular Weight	200.28 g/mol
Synonyms	Boc-ACMA; 1-(((tert-Butoxycarbonyl)amino)methyl)cyclobutan-3-amine; tert-Butyl N-[(3-aminocyclobutyl)methyl]carbamate; (3-Aminocyclobutyl)methylcarbamic acid tert-butyl ester; N-Boc-1,3-cyclobutanedimethanamine; 3-(Boc-aminomethyl)cyclobutanamine; ACMA-Boc; tert-Butyl [(3-aminocyclobutyl)methyl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl ((3-Aminocyclobutyl)Methyl)Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support projects requiring material for GLP or early GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the certificate of analysis. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.