Description

(4-Hydroxymethyl-Cyclohexyl)-Carbamic Acid tert-Butyl Ester CAS NO 1334495-35-0 is a protected amino alcohol derivative, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in the orthogonal protection of both the amine and alcohol functionalities, enabling selective deprotection strategies for complex molecule assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Peptide Mimetics & Conjugate Chemistry: Used to introduce functionalized cyclohexyl scaffolds into peptide backbones or to create bioconjugates, enhancing metabolic stability and bioavailability.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides, leveraging its chiral and functionalized structure.
• Chiral Auxiliary & Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric catalysis.
• Polymer & Material Science: Monomer or cross-linking agent for specialty polymers, coatings, and resins requiring specific mechanical or chemical properties.
• Custom Synthesis & Process R&D: Employed in contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects and route scouting.

Basic Information

Product Name	(4-Hydroxymethyl-Cyclohexyl)-Carbamic Acid tert-Butyl Ester
CAS No.	1334495-35-0
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	tert-Butyl N-[(4-Hydroxymethyl)cyclohexyl]carbamate; 4-((tert-Butoxycarbonyl)aminomethyl)cyclohexanol; N-Boc-4-(hydroxymethyl)cyclohexylamine; Boc-4-(Hydroxymethyl)cyclohexylamine; (trans-4-Hydroxymethylcyclohexyl)carbamic Acid tert-Butyl Ester; (cis-4-Hydroxymethylcyclohexyl)carbamic Acid tert-Butyl Ester; 4-(Boc-aminomethyl)cyclohexanol; 4-(Hydroxymethyl)cyclohexylcarbamic Acid 1,1-Dimethylethyl Ester
EINECS	Contact for details

Quality Control

Our (4-Hydroxymethyl-Cyclohexyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged operations to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for specific isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.