Description

(2-Fluoro-5-(Morpholinomethyl)Phenyl)Boronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a fluorinated aromatic ring and a morpholine moiety, which are key pharmacophores in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing new active ingredients, particularly for creating complex, drug-like molecules through efficient palladium-catalyzed transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: Used extensively in Pd-catalyzed carbon-carbon bond formation to construct biaryl and heterobiaryl scaffolds, which are core structures in many drugs and agrochemicals.
• Agrochemical Research & Development: Employed in creating novel herbicides, fungicides, and insecticides by introducing the fluoro-phenyl-morpholine motif into lead structures.
• Material Science & OLED Development: Serves as a building block for synthesizing advanced organic electronic materials, such as charge-transport layers or emitters for organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) agents due to its reactive boronic acid handle.
• Library Synthesis for Drug Discovery: Integral for high-throughput and parallel synthesis in medicinal chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	(2-Fluoro-5-(Morpholinomethyl)Phenyl)Boronic Acid
CAS No.	1334399-67-5
Molecular Formula	C11H15BFNO3
Molecular Weight	239.06 g/mol
Synonyms	[2-Fluoro-5-(morpholin-4-ylmethyl)phenyl]boronic acid; 2-Fluoro-5-(morpholinomethyl)benzeneboronic acid; (2-Fluoro-5-morpholinomethylphenyl)boronic acid; B-[2-Fluoro-5-(morpholinomethyl)phenyl]boronic acid; 5-(Morpholinomethyl)-2-fluorophenylboronic acid; 2-Fluoro-5-(4-morpholinylmethyl)benzeneboronic acid; CAS 1334399-67-5
EINECS	Contact for details

Quality Control

Our (2-Fluoro-5-(Morpholinomethyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP and ISO 9001 compliant processes for pharmaceutical-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.