Description

Sulfamethizole-13C6 is a stable isotope-labeled analog of the sulfonamide antibiotic Sulfamethizole, where six carbon atoms are replaced with the Carbon-13 isotope. This compound is essential as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and regulatory testing facilities for applications in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Sulfamethizole and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used to track and quantify the parent drug and its metabolic pathways in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Ensures method accuracy, precision, and compliance with regulatory guidelines (FDA, EMA).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Provides reliable data for modeling drug exposure and effect relationships.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports studies aiming to optimize dosing regimens and ensure patient safety.
• Quality Control in Pharmaceutical Manufacturing: Can be used in analytical procedures to monitor drug substance and product quality.
• Forensic and Anti-Doping Analysis: Aids in the definitive identification and quantification of sulfonamides in forensic toxicology and sports doping control.

Basic Information

Product Name	Sulfamethizole-13C6
CAS No.	1334378-92-5
Molecular Formula	C9[13C]6H10N4O2S2
Molecular Weight	~278.3 (base on 13C6 isotope)
Synonyms	4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)-13C6-benzenesulfonamide; 13C6-Sulfamethizole; [13C6]-Sulfamethizole; Sulfamethizole (13C6); Isotopically Labeled Sulfamethizole; Sulfamethizole Internal Standard; Stable Isotope-Labeled Sulfonamide; 2-(p-Aminobenzenesulfonamido)-5-methyl-1,3,4-thiadiazole-13C6
EINECS	Contact for details

Quality Control

Every batch of Sulfamethizole-13C6 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (typically ≥99% 13C6), chemical purity (by HPLC), and identity confirmation (by MS and NMR). Our quality commitment ensures the material meets the stringent requirements for use in regulated bioanalytical laboratories under GLP and GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (13C6)	≥99.0%
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.