Description

(3-((2,2,2-Trifluoroethoxy)Methyl)Phenyl)Boronic Acid is a specialized organoboron compound featuring a phenyl ring substituted with both a trifluoroethoxymethyl group and a boronic acid functionality. This unique structure makes it a valuable building block in modern synthetic chemistry, particularly for cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients. The compound, identified by CAS No. 1334218-47-1, offers a pathway to introduce complex fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoroethoxy group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or building block for developing novel polymers, liquid crystals, or organic electronic materials with specific fluorinated properties.
• Suzuki-Miyaura Cross-Coupling: Acts as a critical boron reagent for forming carbon-carbon bonds between aromatic rings, a fundamental reaction in medicinal and process chemistry.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and bioconjugates that leverage the boronic acid group's affinity for diols.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated boronic acid.

Basic Information

Product Name	(3-((2,2,2-Trifluoroethoxy)Methyl)Phenyl)Boronic Acid
CAS No.	1334218-47-1
Molecular Formula	C9H10BF3O3
Molecular Weight	233.98 g/mol
Synonyms	[3-[(2,2,2-Trifluoroethoxy)methyl]phenyl]boronic acid; 3-((2,2,2-Trifluoroethoxy)methyl)benzeneboronic acid; (3-((2,2,2-Trifluoroethoxy)methyl)phenyl)boronic acid; B-[3-[(2,2,2-Trifluoroethoxy)methyl]phenyl]boronic acid; 3-(Trifluoroethoxymethyl)phenylboronic acid; 3-(2,2,2-Trifluoroethoxymethyl)phenylboronic acid; Boronic acid, B-[3-[(2,2,2-trifluoroethoxy)methyl]phenyl]- (9CI)
EINECS	Contact for details

Quality Control

Our (3-((2,2,2-Trifluoroethoxy)Methyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets exacting specifications for research and production use. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.