Description

Nhs-Peg4-(m-Peg12)3-Ester is a multi-arm, heterobifunctional polyethylene glycol (PEG) crosslinker featuring an N-hydroxysuccinimide (NHS) ester group for efficient amine coupling. This compound is engineered to provide controlled spacing and enhanced aqueous solubility for bioconjugation and nanomaterial surface modification. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced material science who require precise and stable linkages.

Application

• Bioconjugation and Protein-Polymer Conjugation: Used to attach peptides, proteins, or antibodies to other biomolecules, nanoparticles, or solid surfaces via stable amide bonds.
• ADC (Antibody-Drug Conjugate) Linker: Serves as a functional component in the design of ADC payload linkers, offering a hydrophilic PEG spacer to improve solubility and pharmacokinetics.
• Hydrogel Formation: Acts as a crosslinking agent for creating PEG-based hydrogels for 3D cell culture, drug delivery systems, and tissue engineering scaffolds.
• Surface Functionalization: Enables the modification of gold nanoparticles, quantum dots, and other nanomaterials with targeting ligands or biomolecules for diagnostic and therapeutic applications.
• Diagnostic Reagent Synthesis: Employed in the development of enzyme conjugates and labeled probes for ELISA, lateral flow assays, and other immunoassay platforms.
• Polymer Chemistry: Used as a macromolecular building block or initiator for synthesizing complex, branched polymer architectures with defined functionality.

Basic Information

Product Name	Nhs-Peg4-(m-Peg12)3-Ester
CAS No.	1334178-03-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NHS-PEG4-(mPEG12)3-ester; N-Hydroxysuccinimide ester of tetraethylene glycol branched trimer of monomethoxy dodecaethylene glycol; mPEG12-tris-PEG4-NHS ester; Heterobifunctional PEG crosslinker, NHS-PEG4-(mPEG12)3; (mPEG12)3-PEG4-NHS Ester; Multi-arm PEG-NHS ester; Branched PEG NHS ester
EINECS	Contact for details

Quality Control

Our Nhs-Peg4-(m-Peg12)3-Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and functional group analysis, to ensure consistency and performance. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis of the active NHS ester group.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Substitution (NHS Ester)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.