Description

Dnp-Peg12-Acid CAS NO 1334178-00-5 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dinitrophenyl (DNP) group and a terminal carboxylic acid. This compound is engineered to facilitate the controlled conjugation of biomolecules, offering a hydrophilic spacer arm to enhance solubility and reduce immunogenicity. It is an essential tool for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the creation of stable, functionalized constructs for targeted delivery and diagnostics.

Application

• Bioconjugation Reagent: Used for coupling peptides, proteins, or antibodies via the carboxylic acid group to amine-containing molecules.
• ADC (Antibody-Drug Conjugate) Development: Serves as a cleavable linker component, where the DNP group can be utilized for specific release mechanisms or as a protective moiety.
• Proteomics Research: Acts as a functionalized spacer in the synthesis of activity-based probes or affinity tags.
• Polymer Chemistry: Employed as a macromonomer or building block for synthesizing functionalized PEG-based hydrogels and smart materials.
• Diagnostic Assay Development: Facilitates the labeling of detection molecules (e.g., enzymes, fluorophores) for immunoassays and biosensors.
• Drug Delivery Systems: Incorporated into nanocarrier designs (liposomes, micelles) to enable surface functionalization and targeted ligand attachment.

Basic Information

Item	Detail
Product Name	Dnp-Peg12-Acid
CAS No.	1334178-00-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2,4-Dinitrophenyl-PEG12-acid; DNP-PEG12-COOH; α-(2,4-Dinitrophenyl)-ω-carboxypentadecaethylene glycol; DNP-PEG12-Acid; 2,4-DNP-PEG12-acid; Heterobifunctional PEG DNP Acid; DNP-Polyethylene Glycol12-Acid
EINECS	Contact for details

Quality Control

Our Dnp-Peg12-Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing the specific results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant to maintain stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.