Description

Cbz-n-Amido-Peg6-Acid CAS NO 1334177-80-8 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a carboxybenzyl (Cbz) protected amine and a terminal carboxylic acid group. This bifunctional linker is engineered for precision bioconjugation and the synthesis of complex molecular architectures, offering controlled reactivity and enhanced solubility. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, particularly for creating antibody-drug conjugates (ADCs), peptide modifications, and hydrogel networks.

Application

• Bioconjugation & ADC Development: A key reagent for site-specific conjugation of cytotoxic drugs to antibodies or proteins via its amine and carboxyl termini.
• Peptide & Protein Modification: Used to introduce PEG spacers (PEGylation) to improve pharmacokinetic properties like solubility, stability, and circulation half-life.
• Polymer & Dendrimer Synthesis: Serves as a versatile monomer or linker for constructing functionalized polymers, dendrimers, and cross-linked networks.
• Probe & Diagnostic Reagent Fabrication: Facilitates the attachment of labels, dyes, or targeting moieties to biomolecules for imaging and diagnostic assays.
• Drug Delivery System Engineering: Incorporated into nanocarriers, micelles, and liposomes to create smart, stimuli-responsive delivery platforms.
• Surface Functionalization: Used to modify material surfaces with bioactive ligands to enhance biocompatibility and specific cell interactions.

Basic Information

Product Name	Cbz-n-Amido-Peg6-Acid
CAS No.	1334177-80-8
Molecular Formula	C31H51N3O12
Molecular Weight	657.75 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-3,6,9,12,15,18-hexaoxahenicosane-1,21-dioic acid 21-amide; 1-[(Benzyloxy)carbonylamino]-3,6,9,12,15,18-hexaoxahenicosane-21-oic acid; Carbobenzoxy-PEG6-acid; Cbz-NH-PEG6-COOH; Fmoc-PEG6-acid (related); Z-NH-PEG6-acid; Amido-PEG6-Cbz-acid; Benzyl N-[17-carboxy-3,6,9,12,15-pentaoxaheptadecyl]carbamate
EINECS	Contact for details

Quality Control

Our Cbz-n-Amido-Peg6-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed specifications upon request, supporting compliance with research and cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	Conforms (657.75 g/mol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.