Description

Mal-PEG6-COOH is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group at one terminus and a carboxylic acid at the other. This compound is essential for creating stable, site-specific bioconjugates, particularly in the development of antibody-drug conjugates (ADCs) and other therapeutic biologics. It is a critical reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise and reliable crosslinking strategies.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic payloads to antibodies via thiol-maleimide chemistry.
• Protein and Peptide Modification: PEGylation of therapeutic proteins to improve solubility, stability, and pharmacokinetic profiles.
• Biomolecule Immobilization: Covalent attachment of thiol-containing biomolecules (e.g., peptides, antibodies) to carboxyl-functionalized surfaces for biosensor and microarray fabrication.
• Nanoparticle Functionalization: Surface engineering of liposomes, polymersomes, and other nanoparticles for targeted drug delivery systems.
• Diagnostic Reagent Synthesis: Conjugation of enzymes, fluorophores, or other reporter molecules to antibodies or proteins for immunoassays.
• Crosslinking Agent: As a versatile spacer to bridge thiol- and amine-containing molecules in bioconjugation workflows.

Basic Information

Product Name	Mal-PEG6-COOH
CAS No.	1334177-79-5
Molecular Formula	C27H47NO12
Molecular Weight	577.67 g/mol
Synonyms	Maleimide-PEG6-acid; 3-[2-[2-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic Acid; Mal-PEG6-acid; Maleimide-PEG6-COOH; 1-(2-(2-(2-(2-(2-(2-Carboxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione; PEG6 Maleimide Acetic Acid; mPEG6-Mal
EINECS	Contact for details

Quality Control

Our Mal-PEG6-COOH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.