Description

3-Fluoro-4-(Piperidin-1-Ylmethyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling reactions with a fluorinated piperidine moiety that can impart desirable pharmacological properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active compounds and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as an essential coupling partner for constructing biaryl and heterobiaryl scaffolds, a fundamental reaction in creating complex organic molecules.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides, where the fluorine atom and piperidine structure can enhance bioactivity and environmental stability.
• Material Science: Utilized in the creation of organic electronic materials, such as those for OLEDs or organic semiconductors, where precise molecular architecture is required.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes to study biological systems.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries to identify new leads in drug discovery campaigns.

Basic Information

Product Name	3-Fluoro-4-(Piperidin-1-Ylmethyl)Phenylboronic Acid
CAS No.	1334173-50-0
Molecular Formula	C13H19BFNO2
Molecular Weight	251.11 g/mol
Synonyms	3-Fluoro-4-(piperidin-1-ylmethyl)benzeneboronic acid; (3-Fluoro-4-((piperidin-1-yl)methyl)phenyl)boronic acid; 3-Fluoro-4-(1-piperidinylmethyl)phenylboronic acid; B-[3-Fluoro-4-(piperidin-1-ylmethyl)phenyl]boronic acid; 4-Borono-2-fluoro-α-(1-piperidinyl)benzenemethanol (tautomer); CAS 1334173-50-0; FC-004 (Potential internal/research code)
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-4-(Piperidin-1-Ylmethyl)Phenylboronic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.