Description

Biotin-Peg11-Mal CAS NO 1334172-60-9 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a biotin group for affinity capture and a maleimide (Mal) group for site-specific conjugation to thiols. This compound is engineered to facilitate the stable and oriented bioconjugation of biomolecules, which is critical for developing advanced diagnostic and therapeutic platforms. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, targeted drug delivery, and the development of biosensors and diagnostic assays.

Application

• Bioconjugation Reagent: For the site-specific, covalent attachment of peptides, proteins, or antibodies containing free thiol groups (-SH) to biotinylated surfaces or molecules.
• ADC (Antibody-Drug Conjugate) Linker Development: Serves as a functionalized PEG spacer to connect cytotoxic payloads to targeting antibodies, enhancing solubility and pharmacokinetics.
• Diagnostic Assay Development: Used to create streptavidin/avidin-based detection systems for ELISA, lateral flow assays, and other immunoassay formats.
• Surface Functionalization: Immobilization of thiol-containing biomolecules onto biotin-coated chips, beads, or plates for SPR, microarray, or pull-down assays.
• Nanoparticle & Liposome Targeting: Conjugation of targeting ligands to nanocarriers for active targeting in drug delivery research.
• Protein & Peptide Labeling: Introduction of a biotin tag onto cysteine residues for purification, detection, or interaction studies.
• Crosslinking Agent: For studying protein-protein interactions or creating defined macromolecular complexes.
• Tool Compound for Chemical Biology: Enables probing and manipulation of biological systems with high specificity in research settings.

Basic Information

Product Name	Biotin-Peg11-Mal
CAS No.	1334172-60-9
Molecular Formula	C58H100N4O26S
Molecular Weight	1333.5 g/mol
Synonyms	Biotin-PEG11-Maleimide; Maleimide-PEG11-Biotin; Biotin-Polyethylene Glycol-Maleimide (n=11); Biotinylated PEG Maleimide; 5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
EINECS	Contact for details

Quality Control

Our Biotin-Peg11-Mal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and functional group integrity are available upon request to support your research and development documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Integrity (Maleimide)	≥ 90% active
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.