Description

α,α-Difluoro-3-Methyl-Benzeneacetonitrile is a versatile fluorinated aromatic nitrile building block, distinguished by its difluoromethylene group adjacent to the cyano functionality. This molecular architecture is critical for introducing metabolic stability and modulating lipophilicity in advanced chemical synthesis. It serves as a key intermediate for researchers and manufacturers in the pharmaceutical and agrochemical sectors, enabling the development of novel active ingredients. The compound's unique reactivity profile makes it valuable for constructing complex molecules where fluorine substitution is desired.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and stability.
• Fluorinated Polymer Modifiers: Incorporated into specialty polymers to alter surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions, nucleophilic substitutions, and cyano group transformations for complex molecule assembly.
• Positron Emission Tomography (PET) Tracer Precursor: Potential use in the radiosynthesis of fluorine-18 labeled compounds for medical imaging.

Basic Information

Product Name	α,α-Difluoro-3-Methyl-Benzeneacetonitrile
CAS No.	1334146-40-5
Molecular Formula	C9H7F2N
Molecular Weight	167.16 g/mol
Synonyms	2,2-Difluoro-2-(3-methylphenyl)acetonitrile; (3-Methylphenyl)difluoroacetonitrile; α,α-Difluoro-m-toluyl cyanide; 3-Methyl-α,α-difluorobenzeneacetonitrile; m-Tolyl(difluoro)acetonitrile; Difluoro(3-methylphenyl)acetonitrile; 2-(3-Methylphenyl)-2,2-difluoroacetonitrile
EINECS	Contact for details

Quality Control

Our α,α-Difluoro-3-Methyl-Benzeneacetonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment supports applications requiring high-purity intermediates for GMP or research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to its chemical nature, it should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.