Description

tert-Butyl 4-Bromo-3-Cyano-5,6-Dihydro-1,7-Naphthyridine-7(8H)-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced pharmaceutical and agrochemical research. This compound is critical for medicinal chemists seeking to introduce a bromo-cyano-substituted dihydronaphthyridine core into novel molecular architectures. It is primarily utilized by R&D organizations and fine chemical manufacturers engaged in the synthesis of complex active pharmaceutical ingredients (APIs) and other biologically active compounds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of kinase inhibitors and other small molecule therapeutics targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies due to its reactive bromo and cyano functional groups.
• Agrochemical Development: Employed in the research and development of novel herbicides and fungicides, leveraging the naphthyridine scaffold.
• Chemical Biology Probes: Acts as a versatile scaffold for creating molecular probes to study biological processes and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, multi-step organic transformations.
• Material Science Research: Investigated as a potential building block for organic electronic materials and ligands in catalytic systems.

Basic Information

Product Name	tert-Butyl 4-Bromo-3-Cyano-5,6-Dihydro-1,7-Naphthyridine-7(8H)-Carboxylate
CAS No.	1333996-55-6
Molecular Formula	C₁₄H₁₄BrN₃O₂
Molecular Weight	336.18 g/mol
Synonyms	7-Boc-4-bromo-3-cyano-5,6,7,8-tetrahydro-1,7-naphthyridine; tert-Butyl 4-bromo-3-cyano-5,6,7,8-tetrahydro-1,7-naphthyridine-7-carboxylate; 4-Bromo-3-cyano-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,7-naphthyridine; 7-(tert-Butoxycarbonyl)-4-bromo-3-cyano-5,6,7,8-tetrahydro-1,7-naphthyridine; 1333996-55-6; 4-Bromo-3-cyano-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Bromo-3-Cyano-5,6-Dihydro-1,7-Naphthyridine-7(8H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.