Description

T-Boc-n-Amido-Peg3-Propargyl is a specialized bifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group and a tert-butyloxycarbonyl (Boc)-protected amine. This compound is engineered for precision in bioconjugation and materials science, enabling controlled, site-specific coupling reactions via click chemistry. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and the synthesis of advanced polymer materials.

Application

• ADC (Antibody-Drug Conjugate) Development: As a key linker component for attaching cytotoxic payloads to monoclonal antibodies via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Peptide and Protein Modification: For site-specific PEGylation to enhance stability, solubility, and pharmacokinetic profiles of therapeutic biomolecules.
• Polymer Chemistry: Serves as a functional monomer or cross-linker in the synthesis of smart hydrogels, drug delivery systems, and functionalized surfaces.
• Diagnostic Reagent Synthesis: Used to conjugate fluorescent dyes, biotin, or other reporter molecules to targeting ligands for assay development.
• Materials Science: Facilitates the creation of functionalized nanomaterials and surfaces with tailored biological activity.
• Chemical Biology Probes: Enables the construction of activity-based probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	T-Boc-n-Amido-Peg3-Propargyl
CAS No.	1333880-60-6
Molecular Formula	C19H33NO7
Molecular Weight	387.47 g/mol
Synonyms	1-Boc-amino-3,6,9-trioxa-11-undecyne; 2,5,8,11-Tetraoxatetradec-13-yn-1-amine, 14-(1,1-dimethylethoxy)carbonyl]-; tert-Butyl (17-oxo-3,6,9,12-tetraoxa-16-azaheptadec-1-yn-16-yl)carbamate; Boc-NH-PEG3-propargyl; Boc-Amine-PEG3-Alkyne; Propargyl-PEG3-Boc-amine; T-Boc-N-amido-PEG3-propargyl
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg3-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and cGMP-grade applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.