Description

3-Fluoro-4-((2,2,2-trifluoroethoxy)methyl)phenylboronic acid is a specialized organoboron compound that serves as a critical building block in modern synthetic chemistry. Its value lies in its ability to participate in key cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients containing fluorine and trifluoroethoxy motifs.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the fluorine atoms for enhanced biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the creation of labeled compounds and molecular probes for studying biological pathways and protein interactions.
• Catalyst Ligand Development: Acts as a starting material for synthesizing sophisticated ligand systems used in asymmetric catalysis and transition metal complexes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring this specific boronic acid derivative.

Basic Information

Product Name	3-Fluoro-4-((2,2,2-trifluoroethoxy)methyl)phenylboronic Acid
CAS No.	1333407-12-7
Molecular Formula	C9H9BF4O3
Molecular Weight	252.0 g/mol
Synonyms	[3-Fluoro-4-[(2,2,2-trifluoroethoxy)methyl]phenyl]boronic acid; (3-Fluoro-4-((2,2,2-trifluoroethoxy)methyl)phenyl)boronic acid; 3-Fluoro-4-(2,2,2-trifluoroethoxymethyl)benzeneboronic acid; 4-Borono-2-fluoro-1-((2,2,2-trifluoroethoxy)methyl)benzene; 2-Fluoro-4-boronobenzyl 2,2,2-trifluoroethyl ether; B-[3-Fluoro-4-[(2,2,2-trifluoroethoxy)methyl]phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-4-((2,2,2-trifluoroethoxy)methyl)phenylboronic acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis including HPLC for purity and identity confirmation via NMR and IR spectroscopy. We provide detailed Certificates of Analysis (COA) with all shipments, documenting critical parameters such as assay, water content (KF), and residual solvent levels to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.